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Glomerulosclerosis is characterized by the scarring and dysfunction of the glomeruli, which are the filtering units of the kidneys. Among the common causes of glomerulosclerosis, certain factors relate directly to damage and stress on the kidneys.

Drug use can lead to nephrotoxicity, particularly with the use of illegal substances or certain medications that may be harmful. Trauma can also lead to acute kidney injury, which, if severe, can result in long-term effects such as glomerulosclerosis. Both of these factors contribute to the pathological processes that eventually disrupt the normal structure and function of the glomeruli.

While other options may include factors that influence the risk of chronic kidney disease or general health, they do not specifically correlate to the primary causes of glomerulosclerosis. Understanding these connections is vital in clinical practice to identify at-risk populations and implement preventive strategies effectively.