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The presence of proteinuria is indicative of glomerulosclerosis because this condition involves damage to the glomeruli, the structures in the kidneys responsible for filtering blood. When glomerulosclerosis occurs, the integrity of the glomeruli is compromised. This damage results in an increased permeability of the filtration barrier, allowing proteins—such as albumin—to pass through into the urine. Typically, healthy kidneys do not allow significant amounts of protein to enter the urine, so the presence of proteinuria is a key clinical sign of kidney damage and is frequently observed in various kidney diseases, including glomerulosclerosis.

Other options do not directly reflect the condition’s hallmark signs. Low blood pressure may be associated with various other conditions but is not a direct indication of glomerulosclerosis. Cloudy urine can suggest the presence of other substances like bacteria or crystals but is not specific to glomerulosclerosis. High glucose levels may indicate diabetes or other metabolic disorders, which could also result in kidney issues but do not specifically indicate glomerulosclerosis.